In 2000, Environmental Health Perspectives published a Supplement (Volume 108, Number S2, May 2000) focused exclusively on the health risks associated with Trichloroethylene.

From the introduction to the volume:

This monograph comprises 16 articles on the state of the science regarding health risks of trichloroethylene (TCE) that were sponsored by the U.S. Environmental Protection Agency (U.S. EPA), the U.S. Air Force, the U.S. Department of Energy, the National Institute of Environmental Health Sciences, and the Halogenated Solvents Industry Alliance in support of the U.S. EPA trichloroethylene risk assessment. TCE, a chlorinated solvent, was widely used for metal degreasing and is now a common contaminant at Superfund sites and many Department of Defense facilities.

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These articles comprise the state of the science on issues related to TCE risk assessment. As part of the publication process, these articles have undergone peer review by the Environmental Health Perspectives' editorial board. Staff of the National Center for Environmental Assessment at the U.S. EPA will use these articles to write the health risk assessment for TCE, which will include an integrated summary and risk characterization. The updated risk assessment will be peer reviewed by a panel of experts convened by the U.S. EPA. Comments from the public at large will be a part of this review. The U.S. EPA staff will then address these comments with the goal of making the assessment available in the Integrated Risk Information System (IRIS) (1), the U.S. EPA database that contains chemical-specific risk assessment information.

Note the description of the role this volume was intended to play in the EPA's health risk assessment for TCE. It was (partly) on the basis of this volume that EPA wrote its 2001 Draft in which it 1) declared TCE exposure is associated with several adverse health effects, including neurotoxicity, immunotoxicity, developmental toxicity, liver toxicity, kidney toxicity, endocrine effects, and several forms of cancer and 2) characterized TCE as highly likely to produce cancer in humans.

One article we found of particular interest was the meta-analysis conducted by Daniel Wartenberg et. al entitled Trichloroethylene and Cancer: Epidemiologic Evidence. Its findings include:

Sites that show the most consistent and compelling results with respect to TCE exposure and cancer are the kidney and liver. The next most compelling results with respect to TCE exposure are for Hodgkin's disease, non-Hodgkin's lymphoma, and cervical cancer. For dry cleaners and laundry workers, presumably due to PERC exposure, the most compelling results are found for kidney, liver, cervical, lung, esophageal, and pancreatic cancers and multiple myeloma. Weaker results were found for laryngeal, colon, and prostate cancer with TCE exposure, and for bladder cancer among TCE-exposed dry cleaners and laundry workers.

Read the full article for more. Or check out the whole Supplement here.