The following story, published in the Lexington Herald-Leader (KY) this week, reveals the origin of the recent study confirming links between TCE and Parkinsons:

Chemical linked to Parkinson's disease
By Sarah Vos
SVOS@HERALD-LEADER.COM

In the late 1970s, Eddie Abney cleaned grease from metal gauges at a Berea factory using a chemical solvent called trichloroethylene, or TCE. The chemical, which is still used today as an industrial degreaser, soaked through his cotton gloves and into his skin. It splattered on his clothes. He breathed in its vapors.

At night, when he came home, he would tell his wife that the smell was killing him.

It may have been.

Researchers at the University of Kentucky have linked industrial use of TCE to Parkinson's disease, which Abney has. It was Abney, 51, who pointed researchers to a possible connection, leading to a study that was published last month in the online version of Annals of Neurology, a journal of the American Neurological Association.

The study shows a clear link between an environmental contaminant and Parkinson's, said Don Gash, the lead researcher.

TCE has been suspected before as a cause of Parkinson's, but the UK study shows a "clear-cut link" from exposure to the chemical to the disease's development, Gash said. "We've connected the dots."

The study found that three people who directly handled TCE at the factory where Abney worked developed Parkinson's disease. An additional 14, who breathed in its vapors, had early symptoms of Parkinson's, but not the disease itself. And 13 more, who were also exposed to vapors, didn't show signs of parkinsonism but had slower fine motor skills than others their age.

[...]

When Abney was diagnosed with Parkinson's in 2001, he and his wife, Susan, wondered whether TCE could have been the cause. Sometimes Parkinson's has a genetic tie, but Eddie Abney didn't have family history of Parkinson's. Environmental factors had been linked to the disease: exposure to certain pesticides or recreational use of MTPT, known commonly as synthetic heroin.

But Abney wondered whether, in his case, it was TCE. He remembered the strong smell of the chemical he had worked with for more than two decades with little protection.

"I had gloves on, but they were just white cotton gloves," Abney said. "If they got wet, they got saturated."

A year after his diagnosis, Abney participated in a clinical drug trial for Parkinson's disease at UK. When he told a researcher his medical history, he mentioned the exposure to TCE, and the fact that others from the factory had Parkinson's. The researcher, Kathyrn Rutland, thought it sounded like a cluster of cases.

"We felt like there was enough there to really get started," said Gash, the lead researcher.

Read the full story here. (Thanks to KM for the tip!)